2. Signaling Pathways
  3. Neuronal Signaling
  4. Monoamine Oxidase

Monoamine Oxidase

MAO

Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Isoform Specific Products:

Monoamine Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14196
    Toloxatone
    		Inhibitor 98.11%
    Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAOA) inhibitor. Antidepressant.
    Toloxatone
  • HY-127109
    Tisolagiline
    		Inhibitor 99.97%
    Tisolagiline (KDS2010) is a reversible MAO-B inhibitor used in Parkinson's disease research.
    Tisolagiline
  • HY-164099
    LSD1/HDAC6-IN-2
    		Inhibitor 99.66%
    LSD1/HDAC6-IN-2 (JBI-802) is an orally active LSD1/HDAC6/MAO-A inhibitor, with IC50 values of 5 nM, 11 nM, and 5 nM, respectively. LSD1/HDAC6-IN-2 can inhibit the growth of multiple myeloma cells MM.1S, MM.1R, and RPMI-8226. LSD1/HDAC6-IN-2 can be used for research on diseases such as acute myeloid leukemia and lymphoma.
    LSD1/HDAC6-IN-2
  • HY-B1083
    Modaline sulfate
    		Inhibitor 99.86%
    Modaline sulfate is a MAO inhibitor, used in the treatment of depression.
    Modaline sulfate
  • HY-130242
    PXS-5120A
    		98.12%
    PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8).
    PXS-5120A
  • HY-N12485
    MAO-A inhibitor 1
    		Inhibitor 98.55%
    MAO-A inhibitor 1 (compound VIII) is a MAO-A inhibitor, with an IC50 of 100 μM.
    MAO-A inhibitor 1
  • HY-119395B
    Kynuramine dihydrochloride
    		Chemical 99.69%
    Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase.
    Kynuramine dihydrochloride
  • HY-131036
    MAO-IN-M30 dihydrochloride
    		Inhibitor 99.25%
    MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease. MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MAO-IN-M30 dihydrochloride
  • HY-100679
    Pirlindole
    		Inhibitor 98.90%
    Pirlindole is a selective and reversible MAO-A inhibitor. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3).
    Pirlindole
  • HY-B0886
    Iproniazid phosphate
    		Inhibitor 99.92%
    Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity.
    Iproniazid phosphate
  • HY-22385
    Salsolidine
    		Inhibitor
    Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
    Salsolidine
  • HY-N6057
    Obtusin
    		Inhibitor 99.10%
    Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.
    Obtusin
  • HY-151388
    hMAO-B/MB-COMT-IN-1
    		Inhibitor 98.04%
    hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
    hMAO-B/MB-COMT-IN-1
  • HY-B1413
    Eprobemide
    		Inhibitor 99.94%
    Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A.
    Eprobemide
  • HY-W012982
    3-Amino-2-oxazolidinone
    		Inhibitor ≥98.0%
    3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active.
    3-Amino-2-oxazolidinone
  • HY-N7598
    Chrysophanol-1-O-β-gentiobioside
    		Inhibitor ≥99.0%
    Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside isolated from Cassia obtusifolia seeds. Chrysophanol-1-O-β-gentiobioside shows selective inhibition of hMAO-A isozyme activity (IC50=96.15 μM).
    Chrysophanol-1-O-β-gentiobioside
  • HY-156255
    MAO-B-IN-25
    		Inhibitor 99.11%
    MAO-B-IN-25 (compound 92) is a selective MAO-B inhibitor with IC50s of 0.5 nM and 240 nM for MAO-A and MAO-B, respectively.
    MAO-B-IN-25
  • HY-B1558A
    Bifemelane hydrochloride
    		Inhibitor 99.86%
    Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.
    Bifemelane hydrochloride
  • HY-10400
    Ladostigil hemitartrate
    		Inhibitor 98.90%
    Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease. Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ladostigil hemitartrate
  • HY-149234
    MAO-B-IN-18
    		Inhibitor 99.84%
    MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures.
    MAO-B-IN-18
Cat. No. Product Name / Synonyms Application Reactivity
Monoamine Oxidase Isoform Comparison

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